Amyloid β-Protein (1-40)
英文名称: Amyloid β-Protein (1-40)
型号:null    抗体货号: HD130002
价格:请致电:010-57128832,18610462672
品牌: 武汉    产品商标: 昊德

Amyloid β-Protein (1-40)

CompanySerial NumberHD130002

ProductNameAmyloid β-Protein (1-40)

Synonym

CASNo.[131438-79-4] net

Sequence(three-letter)H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter)DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula

MolecularFormulaC194H295N53O58S

MolecularWeight4330.09

ReferencesB.A.Yankneret al., Science, 250, 279 (1990)

M.A.Kowalska and K.Badellino, Biochem. Biophys. Res. Commun., 205, 1829 (1994)

A.Klegeris et al., Biochem. Biophys. Res. Commun., 199, 984 (1994)

M.Pitschke et al., Nat. Med., 4, 832 (1998)

G.Bitan et al., Proc. Natl. Acad. Sci. USA, 100, 330 (2003)

D.M.Walsh and D.J.Selkoe, J. Neurochem., 101, 1172 (2007)

A.Jan et al., Nat. Protoc., 5, 1186 (2010)

IllustrationAmyloidβ-protein (1-40) showed both neurotrophic and neurotoxic effects in dependenceon the neuronal age and the concentration of the β-protein. Aβ 1-40 has beenused as well as Aβ 1-42 to detect amyloid β-protein multimers in thecerebrospinal fluid of Alzheimer's disease patients. H-2972, the inverted Aβ1-40 sequence, can be used as inactive control in experiments employing H-1194.For detailed descriptions of the preparation of wild-type and mutant Aβ 1-40monomers and protofibrils please see the paper of Jan, Hartley, and Lashuel.

ConditionOf Storage: -20± 5 °C