DCTN6,动力蛋白激活蛋白6抗体
英文名称: Anti-DCTN6 antibody
型号:null    抗体货号: HZ-7747R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

DCTN6,动力蛋白激活蛋白6抗体

产品编号HZ-7747R
英文名称DCTN6
中文名称动力蛋白激活蛋白6抗体
别 名Dynactin 6; Dynactin subunit p27; Novel RGD containing protein; Protein WS3; WS 3; WS3.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 交换蛋白 细胞骨架 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
DCTN6,动力蛋白激活蛋白6抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量21kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DCTN6
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DCTN6,动力蛋白激活蛋白6抗体PubMedPubMed
产品介绍background:
DCTN6 belongs to the pointed end complex of the dynactin shoulder complex tpgether with the DCTN4, DCTN5 and DCTN6 subunits and ACTR10. DCTN6 contains an RGD (Arg-Gly-Asp) motif in the N terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. The exact function of this gene is not known.

Subunit:
Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity).

Subcellular Location:
Cytoplasm, cytoskeleton (By similarity).

Tissue Specificity:
Ubiquitous.

Similarity:
Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.

Gene ID:
10671

Database links:
Entrez Gene: 10671 Human
SwissProt: O00399 Human
Unigene: 158427 Human
Unigene: 721134 Human

DCTN6,动力蛋白激活蛋白6抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Preservative:  no Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol Species Reactivity:  Recognizes Ras (Q61L), but not wild type Ras protein from vertebrates. Storage Conditions:   Store at -20°C. Avoid freeze / thaw cycles   Western blot:  
Western blot analysis of recombinant Ras proteins. Equal amount of purified Ras Q61H (lane 1), Ras Q61L (lane 2), Ras Q61R (lane 3), kRas WT (lane 4), hRas WT (lane 5), then were loaded and blotted with anti-Ras Q61L mouse monoclonal antibody (Cat. #26193).
Immunofluorescence:  
Immunofluorescence of cells expressing Ras proteins with anti-Ras (Q61L) antibody. HEK293T cells were transfected with pCDNA3-GFP-Ras (Q61L) plasmid, pCDNA3-GFP-Ras (WT) plasmid, pCDNA3-GFP-Ras (Q61H) plasmid, pCDNA3-GFP-Ras (Q61R) plasmid or pCDNA3-GFP-Ras (Q61K) plasmid, then fixed and stained with anti-Ras (Q61L) monoclonal antibody (Cat. #26193).
 

 

Publications:
1.  DNA vaccine elicits an efficient antitumor response by targeting the mutant Kras in a transgenic mouse lung cancer model
    Gene Therapy 21, 888-896 (October 2014)
2.  Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma
    J Clin Pathol. 2015 Aug;68(8):657-60. doi: 10.1136