CHIR99021/GSK3 inhibitor
英文名称: GSK3β inhibitor
型号:null    产品货号: CHIR-02
价格:请致电:010-57128832,18610462672
品牌: usa

Catalog # CHIR-02; CHIR-10; CHIR-50
Description CHIR99021 (CT99021) is a glycogen synthase kinase 3 (GSK3) inhibitor
with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-
99201 does not exhibit cross-reactivity against cyclin-dependent kinases
(CDKs) with 350-fold selectivity toward GSK-3 compared to CDKs .
Ref: Tighe A et al. BMC Cell Biol. 2007 Aug 14;8:34Formulation Powder
Reconstitution Before reconstitution, we recommend a brief spin to drive down any
material dislodged from the bottom of the tube. The compound is soluble
in DMSO.
Stability The powder is stable for at least 2 year if stored at -20 degree C. The
dissolved compound is stable for at least 1 month at 4 degree C, but should
be stored in aliquots at -20 degree C for longer term. Protect from light.
Purity Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR
data available upon request.
Biological Activity In a cell-based assay measuring the activation of the TCF reporter gene, this
compound gives EC50 of 50 nM.M.W.: 465.34
Formula: C22H18Cl2N8
Solubility: DMSO
CAS No.: 252917-06-9

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质量控制:
本产品经过了细菌、真菌、支原体检测。

运输:
采用冰袋保存运输

保存:
产品请避光保存。
未混合前,基础培养基保存于2-8°C,有效期维持一年;其他组分保存于-20°C,有效期能维持一年。混合后请保存于2-8°C,有效期维持一周。
为了维持产品稳定性,请勿反复冻融相关产品。

用途:
本产品只提供给进一步的科研使用,不可应用于治疗等其他方面。