Recombinant Human NT-4
 
Catalog Number:
AF-450-04
Synonyms:
Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)
Description:
NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues). Manufactured using all non-animal reagents.
AA Sequence:
GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.
 
 
 
 
Cross Reactivity:
Mouse, Rat
Research Interests:
Diabetes / Weight Regulation
Neurobiology
Stem Cells & Differentiation
 
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.