Recombinant  Human IL-10
 
Catalog  Number:
AF-200-10
Synonyms:
B-TCGF,  CSIF, TGIF
Description:
IL-10  is an immunosuppressive cytokine produced by a variety of mammalian cell types  including macrophages, monocytes, T cells, B cells and keratinocytes.  IL-10  inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α.   Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated  immune reactions.  Human IL-10 active on murine cells, but murine IL-10 is  inactive on human cells.  Recombinant human IL-10 is an 18.6 kDa protein of 161  amino acid residues. Manufactured using all non-animal reagents.
AA  Sequence:
MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK  ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK  AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N
Source:
E.coli
Purity:
Greater  than 98% by SDS-PAGE gel and HPLC analyses.
Biological  Activity:
Determined  by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells.  The  expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of  ≥ 5 x 105 units/mg.
 
 
 
 
Cross  Reactivity:
Human,  Human + Virus
Research  Interests:
 
 
 
 
AIDS / HIV
 
 
Cancer
 
 
 
Immune  System
 
 
Inflammation
 
 
 
Neurobiology
 
 
Stem  Cells & Differentiation
 
 
 
Allergy
 
 
Transplantation
 
 
Country  of Origin:
USA
Research  Use Only. Not for use in diagnostic or therapeutic procedures.