Recombinant Human Activin A
 
Catalog Number:
AF-120-14E
Synonyms:
none
Description:
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Recombinant human Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues. Manufactured using all non-animal reagents.
AA Sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Source:
E.coli
Purity:
Greater than 97% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
 
 
 
 
Cross Reactivity:
Chicken, Dog, Frog, Mouse, Human + Mouse
Research Interests:
Angiogenesis/ Cardiovascular
Apoptosis
Cancer
Neurobiology
Stem Cells & Differentiation
TGF-β Superfamily
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.