重组小鼠GDF-5/CDMP-1 10ug 英文名称: Recombinant Murine GDF-5/CDMP-1 |
型号:null 产品货号: 315-24 |
价格:请致电:010-57128832,18610462672 |
品牌: 美国 试剂级别: 细胞培养级 |
Recombinant Murine GDF-5 (BMP-14/CDMP-1)Catalog Number: 315-24 Synonyms: BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) Description: GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids. AA Sequence: APLANRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR Source: E.coli Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 1.0-2.0 µg/ml. Research Interests: Country of Origin: USA Research Use Only. Not for use in diagnostic or therapeutic procedures.
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