Recombinant Rat FGF-acidic

Catalog Number:

400-29A

Synonyms:

Fibroblast Growth Factor-acidic, FGF-1, HBGF-1, ECGF-beta

Description:

FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant rat FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.

AA Sequence:

MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D

Source:

E.coli

Purity:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED₅₀ is ≤ 0.1 ng/ml, in the presence of 10 µg/ml heparin, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

Research Interests:

	Angiogenesis/ Cardiovascular		Cancer
	Cell Culture		FGF Superfamily
	Neurobiology		Proliferation
	Stem Cells & Differentiation		Wound Healing

Country of Origin:

USA

Research Use Only. Not for use in diagnostic or therapeutic procedures.