STAT3 Gene Description Signal transducer and activator of transcription 3 (acute-phase response factor) Alternative Names APRF; FLJ20882; MGC16063 Molecular Weight 89 kDa Summary In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.1

Western blot data of an siRNA transfection experiment. A549 cells were lysed 72 hours after transfection. Cells were transfected with Transfection Reagent alone (Lane 1), 100nM ON-TARGETplus siCONTROL Non-Targeting Pool (Lane 2), or 100nM ON-TARGETplus STAT3 siRNA (Lane 3). Western blot data for CyclophilinB is included as a control for equal protein loading.

Special Notes
*siRNA targets Human gene product.

Product #	Description	Pkg. Size
82409	Anti-STAT3 Protein Antibody	120 µl