重组人TPO(促血小板生成素)细胞培养用 英文名称: Recombinant Human TPO |
型号:null 产品货号: HZ-1225 |
价格:请致电:010-57128832,18610462672 |
品牌: 美国 试剂级别: 细胞培养级 |
人促血小板生成素重组蛋白是在大肠杆菌中重组表达的,是一条单链、非糖基化的多肽链,包含有174个氨基酸,分子量为18608Da,其中就包含了Mp1-配体蛋白的受体结合域。 Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. It stimulates the production and differentiation of megakaryocytes,the bone marrow cells that fragment into large numbers of platelets TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
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