PCDHGC4,原钙粘蛋白γC4抗体

产品编号HZ-11160R
英文名称PCDHGC4
中文名称原钙粘蛋白γC4抗体
别 名PCDGL_HUMAN; PCDH gamma C4; PCDH-gamma-C4; PCDHGC3; PCDHGC4; Protocadherin gamma C4; Protocadherin gamma subfamily C 4; Protocadherin gamma-C4; MGC119489; MGC24978.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Sheep,
PCDHGC4,原钙粘蛋白γC4抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量98kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human PCDHGC4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PCDHGC4,原钙粘蛋白γC4抗体PubMedPubMed
产品介绍background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGC4 (protocadherin gamma subfamily C, 4) is a 938 amino acid single-pass type I membrane protein that localizes to the cell membrane and contains six cadherin domains. Expressed as two alternatively spliced isoforms, PCDHGC4 functions as a potential calcium-dependent cell adhesion protein that is thought to be involved in the establishment and maintenance of neuronal connections within the brain. The gene encoding PCDHGC4 maps to a protocadherin gamma gene cluster which is localized to chromosome 5 and contains over 22 protocadherin genes.

Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Subcellular Location:
Cell membrane.

Similarity:
Contains 6 cadherin domains.

Gene ID:
56098

Database links:
Entrez Gene: 56098 Human
Entrez Gene: 93707 Mouse
Omim: 606305 Human
SwissProt: Q9Y5F7 Human
Unigene: 368160 Human

PCDHGC4,原钙粘蛋白γC4抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片

Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Protocadherin gamma C4) Polyclonal Antibody, Unconjugated (HZ-11160R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.