产品名称

ML329 - CID 12387471

产品货号

Axon 2733 CAS [19992-50-8] MF C16H12N2O4SMW 328.34 Purity: 99% Soluble in DMSO Description ML329 is an inhibitor of the MITF molecular pathway (IC50 value of 1.2 μM; TRPM-1 promoter activity) and showed specific activity against MITF-dependent cells (IC50 values of 0.1 and 0.7 μM in SK-MEL-5 and MALME-3M cell lines, respectively). ML329 also reduced the expression of the cell cycle regulator CDK2, and showed CDK1 inhibition (IC50 value of 0.5 μM). KEYWORDS: ML329 | supplier | MITF inhibitor | CID 12387471 | ML 329 | ML-329 | CAS [19992-50-8] | DNA-RNA | MITF | Inhibitor | Transcription Factors | Microphthalmia-associated transcription factor | Melanoma

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ML329 - CID 12387471

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2733

CAS [19992-50-8]

MF C16H12N2O4S
MW 328.34

Purity: 99%
Soluble in DMSO

ML329

Description

ML329 is an inhibitor of the MITF molecular pathway (IC50 value of 1.2 μM; TRPM-1 promoter activity) and showed specific activity against MITF-dependent cells (IC50 values of 0.1 and 0.7 μM in SK-MEL-5 and MALME-3M cell lines, respectively). ML329 also reduced the expression of the cell cycle regulator CDK2, and showed CDK1 inhibition (IC50 value of 0.5 μM).

PW Faloon et al. A Small Molecule Inhibitor of the MITF Molecular Pathway. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012.

P Furet et al. Identification of cylin-dependent kinase 1 inhibitors of a new chemical type by structure-based design and database searching. J Comput Aided Mol Des. 2001 May;15(5):489-95.

Inhibitor of the MITF molecular pathway

Chemical name

4-(1,4-Dioxo-1,4-dihydronaphthalen-2-ylamino)benzenesulfonamide

Parent CAS No.

[19992-50-8]

产品资料