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产品名称 SB 674042
产品货号 Axon 2192 CAS [483313-22-0] MF C24H21FN4O2SMW 448.51 Purity: 99% Optical purity: >99% ee Soluble in DMSO and Ethanol Description Nonpeptide OX1 selective antagonist (Kd value 3.76 nM) with >100 fold selectivity over the OX2 receptor. SB 674042 displays no significant affinity for a range of serotonergic, dopaminergic, adrenergic and purinergic receptors at concentrations up to 10 μM. SB 674042 was also shown to be a competitive, functional antagonist of the OX1 receptor in the calcium mobilisation assay using CHO-DG44_OX1 cell lines. References Certificates Categories Extra info A. Heifetz et al. Study of Human Orexin-1 and -2 G-Protein-Coupled Receptors with Novel and Published Antagonists by Modeling, Molecular Dynamics Simulations, and Site-Directed Mutagenesis. Biochem. 2012, 51, 3178-3197.   C.J. Langmead et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br. J. Pharmacol. 2004, 141, 340-346.   P. Malherbe et al. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX2 receptor. Br. J. Pharmacol. 2009, 156, 1326-1341. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Diabetes & Metabolism Endocrinology A6 Orexin (OX) Nonpeptide OX1 selective antagonist with >100 fold selectivity over the OX2 receptor. Chemical name (S)-(5-(2-fluorophenyl)-2-methylthiazol-4-yl)(2-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)pyrrolidin-1-yl)methanone Parent CAS No. [483313-22-0] Order Size Unit Price Stock 5 mg €99.00 In Stock
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SB 674042

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2192

CAS [483313-22-0]

MF C24H21FN4O2S
MW 448.51

  • Purity: 99%
  • Optical purity: >99% ee
  • Soluble in DMSO and Ethanol

SB 674042

Description

Nonpeptide OX1 selective antagonist (Kd value 3.76 nM) with >100 fold selectivity over the OX2 receptor. SB 674042 displays no significant affinity for a range of serotonergic, dopaminergic, adrenergic and purinergic receptors at concentrations up to 10 μM. SB 674042 was also shown to be a competitive, functional antagonist of the OX1 receptor in the calcium mobilisation assay using CHO-DG44_OX1 cell lines.
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