产品名称

PU-H71 trihydrochloride

产品货号

Axon 1856 CAS [N.A.] MF C18H21IN6O2S.3HClMW 621.75 Purity: 99% Soluble in water Description Potent inhibitor of heat shock protein 90 (Hsp90) with IC50 of 51 nM; inhibits cell growth in a range of breast cancer cell lines; inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells. Note: On the developers request, this product is not for sale for our customers in the United States. References Certificates Categories Extra info SK Moulick et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chem. Biol. 2011, 7, 818–826. E Caldas-Lopes et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc. Natl. Acad. Sci. USA 2009, 106, 8368. H He et al. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J. Med. Chem. 2006, 49(1), 381-90. Certificate of Analysis Material Safety Data Sheet Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Hsp90 EC 3.6 Hsp90 inhibitor Chemical name 8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine trihydrochloride Parent CAS No. [873436-91-0] Order Size Unit Price Stock 5 mg €105.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PU-H71 trihydrochloride

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 1856

CAS [N.A.]

MF C18H21IN6O2S.3HCl
MW 621.75

Purity: 99%
Soluble in water

PU-H71 trihydrochloride

Description

Potent inhibitor of heat shock protein 90 (Hsp90) with IC50 of 51 nM; inhibits cell growth in a range of breast cancer cell lines; inhibit cell proliferation and induce apoptosis in triple-negative breast cancer (TNBC) cells.

Note: On the developers request, this product is not for sale for our customers in the United States.

SK Moulick et al. Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90. Nature Chem. Biol. 2011, 7, 818–826.

E Caldas-Lopes et al. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proc. Natl. Acad. Sci. USA 2009, 106, 8368.

H He et al. Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90. J. Med. Chem. 2006, 49(1), 381-90.

Hsp90 inhibitor

Chemical name

8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine trihydrochloride

Parent CAS No.

[873436-91-0]

产品资料