产品名称

Dorsomorphin dihydrochloride

产品货号

Axon 2150 CAS [1219168-18-9] MF C24H25N5O.2HClMW 472.41 Purity: 99% Soluble in water and DMSO Description Selective inhibitor of BMP signaling; functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation; Also a AMPK inhibitor (Ki value 109 nM) * Note: Dorsomorphin free base (Axon 1708) is also available References Certificates Categories Extra info PB Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2007, 4(1), 33-41. J Hao et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008, 3(8), e2904. JH Boergermann et al. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Intl. J. Biochem. Cell Biol. 2010, 42(11), 1802-1807. Certificate of Analysis Material Safety Data Sheet Apoptosis Stem Cell TGF-β RSTK class I; EC 2.7.11.30 BMP-ALK Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6 Chemical name 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride Parent CAS No. [866405-64-3] Order Size Unit Price Stock 2 mg €65.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Dorsomorphin dihydrochloride

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2150

CAS [1219168-18-9]

MF C24H25N5O.2HCl
MW 472.41

Purity: 99%
Soluble in water and DMSO

Dorsomorphin dihydrochloride

Description

Selective inhibitor of BMP signaling; functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation; Also a AMPK inhibitor (Ki value 109 nM)

* Note: Dorsomorphin free base (Axon 1708) is also available

PB Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 2007, 4(1), 33-41.

J Hao et al. Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells. PLoS ONE 2008, 3(8), e2904.

JH Boergermann et al. Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. Intl. J. Biochem. Cell Biol. 2010, 42(11), 1802-1807.

Inhibitor of BMP signaling. Inhibits ALK2, 3 and 6

Chemical name

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine dihydrochloride

Parent CAS No.

[866405-64-3]

产品资料