产品名称

TMP 195 - TFMO 2

产品货号

Axon 2180 CAS [1314891-22-9] MF C23H19F3N4O3MW 456.42 Purity: 99% Soluble in DMSO Description Selective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 μM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity. KEYWORDS: TMP 195 | supplier | IIa HDAC inhibitor | TFMO 2 | TMP195 | TFMO2 | TMP-195 | TFMO-2 | CAS [1314891-22-9] | Histone | Deacetylase | HDAC | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TMP 195 - TFMO 2

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2180

CAS [1314891-22-9]

MF C23H19F3N4O3
MW 456.42

Purity: 99%
Soluble in DMSO

TMP 195

Description

Selective and cell-active class IIa histone deacetylase (HDAC) inhibitor, with IC50 values of 111, 106, 46, 9 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively; >100 fold more selective vs other HDACs (IC50: >10 μM).The trifluoromethyloxadiazole (TFMO) moiety in TMP 195 as a new metal binding group circumvents the selectivity and pharmacologic liabilities of hydroxamates groups used in other metalloenzyme inhibitors. TMP 195 has a restraint impact on gene expression, and lacks overt cytotoxicity.

M. Lobera et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat. Chem. Biol. 2013, 9, 319-325.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC

HDAC inhibitor (class IIA selective)

Chemical name

N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

Parent CAS No.

[1314891-22-9]

产品资料