产品名称

Mocetinostat - MGCD 0103 | MG 0103

产品货号

Axon 2505 CAS [726169-73-9] MF C23H20N6OMW 396.44 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Class I selective HDAC inhibitor (sub-micromolar IC50 values for HDAC1, HDAC2, and HDAC11, ca 2 μM for HDAC3, and >10 μM for HDAC4-8) with broad spectrum antitumor activity in vitro and in vivo. MGCD 0103 induced hyperacetylation of histones, selectively induced apoptosis, caused cell cycle blockade, and exhibited potent and selective antiproliferative activities against a broad spectrum of human cancer cell lines in vitro. KEYWORDS: Mocetinostat | Supplier | HDAC inhibitor | MGCD 0103 | MG 0103 | MG0103 | MGCD0103 | CAS [726169-73-9] | Histone | HDAC1 | HDAC2 | HDAC3 | HDAC11 | deacetylase | antitumor | hyperacetylation | apoptosis | cell cycle | blockade | isotype-selective

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Mocetinostat - MGCD 0103 | MG 0103

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2505

CAS [726169-73-9]

MF C23H20N6O
MW 396.44

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Mocetinostat

Description

Class I selective HDAC inhibitor (sub-micromolar IC50 values for HDAC1, HDAC2, and HDAC11, ca 2 μM for HDAC3, and >10 μM for HDAC4-8) with broad spectrum antitumor activity in vitro and in vivo. MGCD 0103 induced hyperacetylation of histones, selectively induced apoptosis, caused cell cycle blockade, and exhibited potent and selective antiproliferative activities against a broad spectrum of human cancer cell lines in vitro.

KEYWORDS: Mocetinostat | Supplier | HDAC inhibitor | MGCD 0103 | MG 0103 | MG0103 | MGCD0103 | CAS [726169-73-9] | Histone | HDAC1 | HDAC2 | HDAC3 | HDAC11 | deacetylase | antitumor | hyperacetylation | apoptosis | cell cycle | blockade | isotype-selective

T. Beckers et al. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int J Cancer. 2007 Sep 1;121(5):1138-48.

M. Fournel et al. MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther. 2008 Apr;7(4):759-68.

N. Zhou et al. Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ylpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor. J Med Chem. 2008 Jul 24;51(14):4072-5.

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC

Class I selective HDAC inhibitor with broad spectrum antitumor activity

Chemical name

N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide

Parent CAS No.

[726169-73-9]

产品资料