产品名称

GSK481 - GSK'481

产品货号

Axon 2608 CAS [1622849-58-4] MF C21H19N3O4MW 377.39 Purity: 98% Soluble in DMSO Description Potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of S166 phosphorylation of hWT RIP1) exhibiting a remarkable specificity over >450 other kinases. GSK'481 protects against TNF-induced inflammation and lethal shock. KEYWORDS: GSK481 | supplier | RIP1 kinase inhibitor | GSK'481 | CAS [1622849-58-4] | Phosphorylation | RIP | inflammation | TNF | RIPK1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GSK481 - GSK'481

Based on 5 reference(s) in Google Scholar 9 10 5

Axon 2608

CAS [1622849-58-4]

MF C21H19N3O4
MW 377.39

Purity: 98%
Soluble in DMSO

GSK481

Description

Potent inhibitor of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1 or RIP1; IC50 value 2.8 nM for inhibition of S166 phosphorylation of hWT RIP1) exhibiting a remarkable specificity over >450 other kinases. GSK'481 protects against TNF-induced inflammation and lethal shock.

PA Harris et al. DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem. 2016 Mar 10;59(5):2163-78.

P Geserick et al. Absence of RIPK3 predicts necroptosis resistance in malignant melanoma. Cell Death Dis. 2015 Sep 10;6:e1884.

Potent inhibitor of RIP1 kinase and TNF induced inflammation

Chemical name

(S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)isoxazole-3-carboxamide

Parent CAS No.

[1622849-58-4]

产品资料