产品名称

UNC 2250

产品货号

Axon 2346 CAS [1493694-70-4] MF C24H36N6O2MW 440.58 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent Mer kinase inhibitor (in vitro IC50 values 1.7 nM, 270 nM, and 100 nM for Mer, Axl, and Tyro3 RTKs, respectively) with promising selectivity and PK properties. UNC 2250 efficiently inhibited both steady state and ligand-stimulated phosphorylation of Mer, and confirmed functional antitumor activity by exhibiting potential to reduced colony-forming in both rhabdoid tumor cells and NSCLC cells. KEYWORDS: UNC 2250 | supplier | Mer Inhibitor | UNC2250 | CAS [1493694-70-4] | Gas6 | Mer | TAM | RTK | Axl | Tyro3 | antitumor | rhabdoid | NSCLC | lung cancer

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

UNC 2250

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2346

CAS [1493694-70-4]

MF C24H36N6O2
MW 440.58

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

UNC 2250

Description

Potent Mer kinase inhibitor (in vitro IC50 values 1.7 nM, 270 nM, and 100 nM for Mer, Axl, and Tyro3 RTKs, respectively) with promising selectivity and PK properties. UNC 2250 efficiently inhibited both steady state and ligand-stimulated phosphorylation of Mer, and confirmed functional antitumor activity by exhibiting potential to reduced colony-forming in both rhabdoid tumor cells and NSCLC cells.

KEYWORDS: UNC 2250 | supplier | Mer Inhibitor | UNC2250 | CAS [1493694-70-4] | Gas6 | Mer | TAM | RTK | Axl | Tyro3 | antitumor | rhabdoid | NSCLC | lung cancer

W. Zhang et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J. Med. Chem. 2013, 56, 9683-9692.

Angiogenesis Cell Signaling & Oncology Pain & Inflammation Mer RTK class XI; EC 2.7.10.1

Potent Mer kinase inhibitor with promising selectivity and PK properties.

Chemical name

(1r,4r)-4-(2-(butylamino)-5-(5-(morpholinomethyl)pyridin-2-yl)pyrimidin-4-ylamino)cyclohexanol

Parent CAS No.

[1493694-70-4]

产品资料