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产品名称 K 02288
产品货号 Axon 2189 CAS [1431985-92-0] MF C20H20N2O4MW 352.38 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent and highly selective inhibitor of BMP signaling, with low nanomolar IC50 values of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6 respectively and IC50s of 34.4, 302, 321 and 220 nM for other ALKs (3, 4, 5) and ActRIIA respectively.K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos. K02288 provides a useful tool to investigate BMP signaling and to research into stem cell biology and disease models of anemia, musculoskeletal dysplasia and cancer. References Certificates Categories Extra info C.E. Sanvitale et al. A New Class of Small Molecule Inhibitor of BMP Signaling. PLoS One. 2013, 8, e62721.  Certificate of Analysis Material Safety Data Sheet Apoptosis Stem Cell TGF-β RSTK class I; EC 2.7.11.30 BMP-ALK Inhibitor of BMP signaling. Inhibits ALK1, 2, and 6 Chemical name 3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol Parent CAS No. [1431985-92-0] Order Size Unit Price Stock 5 mg €90.00 In Stock
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K 02288

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2189

CAS [1431985-92-0]

MF C20H20N2O4
MW 352.38

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

K 02288

Description

Potent and highly selective inhibitor of BMP signaling, with low nanomolar IC50 values of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6 respectively and IC50s of 34.4, 302, 321 and 220 nM for other ALKs (3, 4, 5) and ActRIIA respectively.K02288 specifically inhibited the BMP-induced Smad pathway without affecting TGF-β signaling and induced dorsalization of zebrafish embryos. K02288 provides a useful tool to investigate BMP signaling and to research into stem cell biology and disease models of anemia, musculoskeletal dysplasia and cancer.
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