| 产品名称 | LY 2940680 - Taladegib | |||
| 产品货号 | Axon 2196 CAS [1258861-20-9] MF C26H24F4N6OMW 512.50 Purity: 99% Soluble in DMSO Description Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4. References Certificates Categories Extra info C. Wang et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 2013, 497, 338-343. P.A. Hipskind et al. Preparation of disubstituted phthalazine derivatives for use as hedgehog pathway antagonists and useful in treatment of cancer. PCT Int. Appl. WO 2010147917 A1 20101223. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Stem Cell Smoothened (SMO) Hedgehog F Small-molecule antagonist of the Smoothened (SMO) receptor Chemical name 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide Parent CAS No. [1258861-20-9] Order Size Unit Price Stock 5 mg €120.00 In Stock | |||
| 产品价格 | 现货询价，电话：010-67529703 | |||
| 产品规格 | ||||
| 产品品牌 | axonmedchem | |||
| 产品概述 | ||||
| 产品详情 |
LY 2940680 - TaladegibAxon 2196 CAS [1258861-20-9] MF C26H24F4N6O
Description
Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4.
Small-molecule antagonist of the Smoothened (SMO) receptor
Chemical name4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide Parent CAS No.[1258861-20-9] |
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