产品名称

ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride

产品货号

Axon 2888 CAS [912445-05-7] MF C13H1N4O.2HClMW 317.21 Purity: 99% Optical purity: Optically pure Soluble in water and DMSO Description Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. The free base of ABT 888 is available as Axon 1893. KEYWORDS: ABT 888 dihydrochloride | supplier | PARP inhibitor | Veliparib dihydrochloride | A 861695 dihydrochloride | A861695 dihydrochloride | A-861695 dihydrochloride | CAS [912445-05-7] | [912444-00-9] | DNA-RNA | PARP | Inhibitor | Enzymes

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride

Based on 8 reference(s) in Google Scholar 8 10 8

Axon 2888

CAS [912445-05-7]

MF C13H1N4O.2HCl
MW 317.21

Purity: 99%
Optical purity: Optically pure
Soluble in water and DMSO

ABT 888 dihydrochloride

Description

Potent and orally bioavailable PARP inhibitor, with Ki values to be 5.2 nM for PARP1 and 2.9 nM for PARP2 respectively; inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents.

The free base of ABT 888 is available as Axon 1893.

CK Donawho et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models. Clin. Cancer Res. 2007, 13, 2728.

P Palma et al. The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res. 2008, 28(5A), 2625-2635.

PARP inhibitor

Chemical name

(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride

Parent CAS No.

[912444-00-9]

产品资料