产品名称

TEPP 46 - ML 265

产品货号

Axon 2240 CAS [1221186-53-3] MF C17H16N4O2S2MW 372.46 Purity: 99% Soluble in DMSO Description Potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Continuous dosing of mice with TEPP 46 decreased the development of human cancer cell xenografts, suggesting that increased pyruvate kinase activity can impair tumorigenesis.TEPP 46 can mimic the enzymatic properties of PKM1 in PKM2-expressing cells, alter cell metabolism, and induces changes in the kinetic properties of PKM2 that are identical to those induced by the endogenous PKM2 activator FBP. KEYWORDS: TEPP 46 | supplier | PKM2 activator | ML 265 | TEPP46 | ML265 | TEPP-46 | ML-265 | CAS [1221186-53-3] | Pyyruvate | PKM2 | Activator | Enzymes | Glycolysis | Warburg | tumorigenesis | cancer | glucose metabolism

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

TEPP 46 - ML 265

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2240

CAS [1221186-53-3]

MF C17H16N4O2S2
MW 372.46

Purity: 99%
Soluble in DMSO

TEPP 46

Description

Potent and selective activator of recombinant pyruvate kinase M2 (PKM2) with half-maximum activating concentration (AC50 value) of 92 nM, and little or no activity versus PKM1, PKL and PKR. Continuous dosing of mice with TEPP 46 decreased the development of human cancer cell xenografts, suggesting that increased pyruvate kinase activity can impair tumorigenesis.TEPP 46 can mimic the enzymatic properties of PKM1 in PKM2-expressing cells, alter cell metabolism, and induces changes in the kinetic properties of PKM2 that are identical to those induced by the endogenous PKM2 activator FBP.