产品名称

Sephin 1 - NSC 65390

产品货号

Axon 2524 CAS [951441-04-6] MF C8H9ClN4MW 196.64 Purity: 99% Soluble in DMSO Description Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin1 selectively disrupted the PPP1R15A-PP1c complex, therebye prolonging eIF2α phosphorylation after stress, delaying translation recovery, and consequently, attenuated expression of stress genes such as the pro-apoptotic protein CHOP. The cytoprotectant prevents protein misfolding, motor deficits, motor neuron loss, and the molecular defects in SOD1 mutant mice. KEYWORDS: Sephin 1 | supplier| |

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Sephin 1 - NSC 65390

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2524

CAS [951441-04-6]

MF C8H9ClN4
MW 196.64

Purity: 99%
Soluble in DMSO

Sephin 1

Description

Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity. In cells, Sephin1 selectively disrupted the PPP1R15A-PP1c complex, therebye prolonging eIF2α phosphorylation after stress, delaying translation recovery, and consequently, attenuated expression of stress genes such as the pro-apoptotic protein CHOP. The cytoprotectant prevents protein misfolding, motor deficits, motor neuron loss, and the molecular defects in SOD1 mutant mice.

I. Das et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42.

Selective PPP1R15A inhibitor devoid of PPP1R15B and α2-adrenergic activity

Chemical name

(E)-2-(2-chlorobenzylidene)hydrazinecarboximidamide

Parent CAS No.

[951441-04-6]

产品资料