产品名称

Begacestat - GSI 953

产品货号

Axon 2117 CAS [769169-27-9] MF C9H8ClF6NO3S2MW 391.74 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective γ-secretase inhibitor (γ-secratase inhibitor, GSI); Capable of reducing both Aβ40 and Aβ42 production in a cell line stably expressing human recombinant APP (EC50 values of 14.8 and 12.4 nM for Aβ40 and Aβ40 respectively). Begacestat was found to have >16-fold selectivity in vitro for the inhibition of APP processing over Notch References Certificates Categories Extra info RL Martone et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J. Pharmacol. Exp. Ther. 2009, 331(2), 598-608. SC Mayer et al. Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2008, 51(23), 7348-7351. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46 Pfizer Licensed Products Selective γ-secretase inhibitor (GSI) Chemical name (S)-5-chloro-N-(4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl)thiophene-2-sulfonamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [769169-27-9] Order Size Unit Price Stock 5 mg €85.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

Begacestat - GSI 953

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2117

CAS [769169-27-9]

MF C9H8ClF6NO3S2
MW 391.74

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Begacestat

Description

Potent and selective γ-secretase inhibitor (γ-secratase inhibitor, GSI); Capable of reducing both Aβ40 and Aβ42 production in a cell line stably expressing human recombinant APP (EC50 values of 14.8 and 12.4 nM for Aβ40 and Aβ40 respectively). Begacestat was found to have >16-fold selectivity in vitro for the inhibition of APP processing over Notch

RL Martone et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J. Pharmacol. Exp. Ther. 2009, 331(2), 598-608.

SC Mayer et al. Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2008, 51(23), 7348-7351.

Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46 Pfizer Licensed Products

Selective γ-secretase inhibitor (GSI)

Chemical name

(S)-5-chloro-N-(4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl)thiophene-2-sulfonamide

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[769169-27-9]

产品资料