产品名称

Z-VAD-FMK - Z-VAD(OMe)-FMK

产品货号

Axon 2159 CAS [187389-52-2] MF C22H30FN3O7MW 467.49 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Pan-caspase inhibitor with in vivo activity (Ki values 18.4 μM, 0.45 μM, and 17.1 μM for Caspase-3, -8, and -9 resp). Z-VAD-FMK inhibits apoptosis by blocking the processing of CPP32, and in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Z-VAD-FMK is a key compound for studies on apoptosis. Product is currently not in stock References Certificates Categories Extra info R. Sadhukhan et al. An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds. Protein Expr. Purif. 2006, 46, 299-308. Y.H. Han et al. Caspase inhibitor decreases apoptosis in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Int. J. Oncol. 2008, 33, 1099-1105. G.P. McStay et al. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ. 2008, 15, 322-331. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology CNS EC 3.4.22.56 Caspase Pan-caspase inhibitor with in vivo activity Chemical name (5S,8S,11S)-methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Parent CAS No. [187389-52-2] Inquire

产品价格

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

Z-VAD-FMK - Z-VAD(OMe)-FMK

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2159

CAS [187389-52-2]

MF C22H30FN3O7
MW 467.49

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

Z-VAD-FMK

Description

Pan-caspase inhibitor with in vivo activity (Ki values 18.4 μM, 0.45 μM, and 17.1 μM for Caspase-3, -8, and -9 resp). Z-VAD-FMK inhibits apoptosis by blocking the processing of CPP32, and in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Z-VAD-FMK is a key compound for studies on apoptosis.

Product is currently not in stock

R. Sadhukhan et al. An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds. Protein Expr. Purif. 2006, 46, 299-308.

Y.H. Han et al. Caspase inhibitor decreases apoptosis in pyrogallol-treated lung cancer Calu-6 cells via the prevention of GSH depletion. Int. J. Oncol. 2008, 33, 1099-1105.

G.P. McStay et al. Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways. Cell Death Differ. 2008, 15, 322-331.

Pan-caspase inhibitor with in vivo activity

Chemical name

(5S,8S,11S)-methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate

Parent CAS No.

[187389-52-2]

产品资料