产品名称

AZD2716

产品货号

Axon 2661 CAS [1845753-81-2] MF C24H23NO3MW 373.44 Purity: 99% Optical purity: 98% e.e. Soluble in 0.1N NaOH (aq) and DMSO Description AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates.

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

AZD2716

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2661

CAS [1845753-81-2]

MF C24H23NO3
MW 373.44

Purity: 99%
Optical purity: 98% e.e.
Soluble in 0.1N NaOH (aq) and DMSO

AZD2716

Description

AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates.

F Giordanetto et al. Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease. ACS Med Chem Lett. 2016 Aug 9;7(10):884-889.

Potent secreted phospholipase A2 (sPLA2) inhibitor

Chemical name

(R)-3-(5'-Benzyl-2'-carbamoylbiphenyl-3-yl)-2-methylpropanoic acid

Parent CAS No.

[1845753-81-2]

产品资料