产品名称

SPHINX31

产品货号

Axon 2714 CAS [1818389-84-2] MF C27H24F3N5O2MW 507.51 Purity: 99% Soluble in DMSO Description SPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo. KEYWORDS: SPHINX31 | supplier | SRPK1 inhibitor | SPHINX 31 | SPHINX-31 | CAS [1818389-84-2] | DNA-RNA | SRPK | Inhibitor | Enzymes | Neovascular Eye Disease | VEGF | SRSF1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

SPHINX31

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2714

CAS [1818389-84-2]

MF C27H24F3N5O2
MW 507.51

Purity: 99%
Soluble in DMSO

SPHINX31

Description

SPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo.

J Batson et al. Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem Biol. 2017 Mar 17;12(3):825-832.

Potent and selective inhibitor of SRPK1 kinase activity

Chemical name

N-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide

Parent CAS No.

[1818389-84-2]

产品资料