产品名称

MPT0B098

产品货号

Axon 2658 CAS [1254363-89-7] MF C20H18N2O3SMW 366.43 Purity: 99% Soluble in DMSO Description Microtubule inhibitor that binds to the colchicine-binding site of tubulin and suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability. MPT0B098 arrests cells in the G2-M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA. KEYWORDS: MPT0B098 | supplier | Microtubule inhibitor | CAS [1254363-89-7] | Cytoskeleton | Tubulin | Inhibitor | colchicine | JAK2/STAT3 | SOCS3 | cell arrest | G2-M | apoptosis | cell migration | HIF-1α

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

MPT0B098

Based on 3 reference(s) in Google Scholar 9 10 3

Axon 2658

CAS [1254363-89-7]

MF C20H18N2O3S
MW 366.43

Purity: 99%
Soluble in DMSO

MPT0B098

Description

Microtubule inhibitor that binds to the colchicine-binding site of tubulin and suppresses JAK2/STAT3 signaling pathway through modulation of SOCS3 stability. MPT0B098 arrests cells in the G2-M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA.