| 产品名称 | EML 425 |
| 产品货号 | Axon 2568 CAS [1675821-32-5] MF C27H24N2O4MW 440.49 Purity: 99% Soluble in DMSO Description Potent, selective and cell permeable reversible dual inhibitor of CBP and p300 (IC50 values 1.1 μM and 2.9 μM, respectively, and practically inactive against the enzymes GCN5 and PCAF), noncompetitive versus both acetyl-CoA and a histone H3 peptide. EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. EML425's potency is comparable to that of C646 (Axon 1781). KEYWORDS: EML 425 | supplier | dual CBP/p300 KAT3 inhibitor | EML425 | CAS [1675821-32-5] | Histone | HAT | Inhibitor | Lysine acyltransferase | H4K5 | H3K9 | G0/G1 arrest | hypodiploid nuclei | C646 |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
EML 425Axon 2568 CAS [1675821-32-5] MF C27H24N2O4
DescriptionPotent, selective and cell permeable reversible dual inhibitor of CBP and p300 (IC50 values 1.1 μM and 2.9 μM, respectively, and practically inactive against the enzymes GCN5 and PCAF), noncompetitive versus both acetyl-CoA and a histone H3 peptide. EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. EML425's potency is comparable to that of C646 (Axon 1781). KEYWORDS: EML 425 | supplier | dual CBP/p300 KAT3 inhibitor | EML425 | CAS [1675821-32-5] | Histone | HAT | Inhibitor | Lysine acyltransferase | H4K5 | H3K9 | G0/G1 arrest | hypodiploid nuclei | C646
Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3)
Chemical name1,3-dibenzyl-5-(4-hydroxy-2,6-dimethylbenzylidene)pyrimidine-2,4,6(1H,3H,5H)-trione Parent CAS No.[1675821-32-5] |
| 产品资料 |
