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产品名称 BMH 21
产品货号 Axon 2462 CAS [896705-16-1] MF C21H20N4O2MW 360.41 Purity: 99% Soluble in 0.1N HCl (aq) Description RNA polymerase I (RNAP1) inhibitor (IC50 values 0.05 µM and 0.07 µM for degradation of RPA194 and translocation of NCL, respectively). BMH-21 intercalates with GC-rich rDNA, inhibits Pol I, and causes activation of p53 and proteasome-mediated degradation of RPA194. Furthermore, BMH21 showed broad and potent anticancer activity in NCI60 cancer cell lines and reduced tumor burden in mouse xenograft assays. References Certificates Categories Extra info L. Colis et al.Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors. J Med Chem. 2014 Jun 12;57(11):4950-61.   K. Peltonen et al. Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. PLoS One. 2010 Sep 27;5(9):e12996. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Immunology RNAP1 p53-Tumor Suppression DNA-damage Response EC 2.7.7.6 Inhibitor of RNA Polymerase I (RNAP1) Chemical name N-(2-(dimethylamino)ethyl)-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide Parent CAS No. [896705-16-1] Order Size Unit Price Stock 10 mg €95.00 In Stock
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BMH 21

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2462

CAS [896705-16-1]

MF C21H20N4O2
MW 360.41

  • Purity: 99%
  • Soluble in 0.1N HCl (aq)

BMH 21

Description

RNA polymerase I (RNAP1) inhibitor (IC50 values 0.05 µM and 0.07 µM for degradation of RPA194 and translocation of NCL, respectively). BMH-21 intercalates with GC-rich rDNA, inhibits Pol I, and causes activation of p53 and proteasome-mediated degradation of RPA194. Furthermore, BMH21 showed broad and potent anticancer activity in NCI60 cancer cell lines and reduced tumor burden in mouse xenograft assays.
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