| 产品名称 | Ispinesib - SB 715992 |
| 产品货号 | Axon 2446 CAS [336113-53-2] MF C30H33ClN4O2MW 517.06 Purity: 99% Optical purity: Optically pure Soluble in DMSO and Ethanol Description The first potent, highly specific small-molecule inhibitor of the human kinesin spindle protein (KSP or KIF11 or Eg5), that induces mitosis-phase (M-phase) arrest followed by apoptosis in either the M-phase (via mitotic catastrophe) or G1-phase of the cell-cycle. Ispinesib alters the ability of KSP to bind to microtubules and inhibits its movement by preventing the release of ADP without preventing the release of the KSP−ADP complex from the microtubule References Certificates Categories Extra info J.P. Holland et al. Fluorinated quinazolinones as potential radiotracers for imaging kinesin spindle protein expression. Bioorg Med Chem. 2013 Jan 15;21(2):496-507. L. Lad et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47(11):3576-85. L. Luo et al. ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism. Nat Chem Biol. 2007 Nov;3(11):722-6. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology EC 3.6.4.4 KSP First potent, highly specific small-molecule inhibitor of human KSP Chemical name (R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide Parent CAS No. [336113-53-2] Order Size Unit Price Stock 5 mg €120.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
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Ispinesib - SB 715992Axon 2446 CAS [336113-53-2] MF C30H33ClN4O2
Description
The first potent, highly specific small-molecule inhibitor of the human kinesin spindle protein (KSP or KIF11 or Eg5), that induces mitosis-phase (M-phase) arrest followed by apoptosis in either the M-phase (via mitotic catastrophe) or G1-phase of the cell-cycle. Ispinesib alters the ability of KSP to bind to microtubules and inhibits its movement by preventing the release of ADP without preventing the release of the KSP−ADP complex from the microtubule
First potent, highly specific small-molecule inhibitor of human KSP
Chemical name(R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide Parent CAS No.[336113-53-2] |
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