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Dimethylenastron - Eg5 inhibitor III

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Axon 2439 CAS [863774-58-7] MF C16H18N2O2SMW 302.39 Purity: 98% Optical purity: Racemate Soluble in DMSO Description Specific potent and cell-permeable inhibitor of the mitotic motor Eg5 (a.k.a. kinesin-5 or KSP; IC50 value 200 nM). Dimethylenastron proved to be >100-times more potent than monastrol, both in vitro and with arresting mitosis of cultured cells. Capable of halting cell cycle progression in mitosis and of inducing apoptosis. Dimethylenastron activates the PI3K/Akt pathway, which in turn causes transcriptional up-regulation of Hsp70. References Certificates Categories Extra info M. Gartner et al. Development and biological evaluation of potent and specific inhibitors of mitotic Kinesin Eg5. Chembiochem. 2005 Jul;6(7):1173-7. M. Liu et al. Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells. J Biol Chem. 2006 Jun 30;281(26):18090-7. M. Liu et al. Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor. Biochem Pharmacol. 2008 Jul 15;76(2):169-78. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology PI3K-Akt-mTOR EC 3.6.4.4 KSP Specific potent and cell-permeable inhibitor of Eg5 (KSP) Chemical name 4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one Parent CAS No. [863774-58-7] Order Size Unit Price Stock 10 mg €105.00 In Stock

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Dimethylenastron - Eg5 inhibitor III

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2439

CAS [863774-58-7]

MF C16H18N2O2S
MW 302.39

Purity: 98%
Optical purity: Racemate
Soluble in DMSO

Dimethylenastron

Description

Specific potent and cell-permeable inhibitor of the mitotic motor Eg5 (a.k.a. kinesin-5 or KSP; IC50 value 200 nM). Dimethylenastron proved to be >100-times more potent than monastrol, both in vitro and with arresting mitosis of cultured cells. Capable of halting cell cycle progression in mitosis and of inducing apoptosis. Dimethylenastron activates the PI3K/Akt pathway, which in turn causes transcriptional up-regulation of Hsp70.