| 产品名称 | Cerdulatinib - PRT 062070 |
| 产品货号 | Axon 2775 CAS [1198300-79-6] MF C20H27N7O3SMW 445.54 Purity: 98% Soluble in DMSO Description Cerdulatinib is an orally active kinase inhibitor that demonstrates activity against Syk and JAK with IC50 values of 32 nM, 12 nM, 6 nM and 8 nM for Syk, JAK1, JAK2 and JAK3, respectively. Cellular assays demonstrated specific inhibitory activity against signaling pathways that use Syk and JAK1/3. Limited inhibition of JAK2 was observed. Potent antitumor activity was observed in a subset of B-cell lymphoma cell lines. KEYWORDS: Cerdulatinib | support | Syk/JAK inhibitor | PRT 062070 | PRT062070 | PRT-062070 | CAS [1198300-79-6] | CAS [1369761-01-2] | B-Cell Transformation | Spleen tyrosine kinase (Syk) | JAK | Inhibitor | Enzymes | B-cell lymphoma |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
Cerdulatinib - PRT 062070Axon 2775 CAS [1198300-79-6] MF C20H27N7O3S
DescriptionCerdulatinib is an orally active kinase inhibitor that demonstrates activity against Syk and JAK with IC50 values of 32 nM, 12 nM, 6 nM and 8 nM for Syk, JAK1, JAK2 and JAK3, respectively. Cellular assays demonstrated specific inhibitory activity against signaling pathways that use Syk and JAK1/3. Limited inhibition of JAK2 was observed. Potent antitumor activity was observed in a subset of B-cell lymphoma cell lines. KEYWORDS: Cerdulatinib | support | Syk/JAK inhibitor | PRT 062070 | PRT062070 | PRT-062070 | CAS [1198300-79-6] | CAS [1369761-01-2] | B-Cell Transformation | Spleen tyrosine kinase (Syk) | JAK | Inhibitor | Enzymes | B-cell lymphoma
Orally active dual Syk/JAK inhibitor
Chemical name4-(Cyclopropylamino)-2-(4-(4-(ethylsulfonyl)piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide Parent CAS No.[1198300-79-6] |
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