产品名称

ARM1 hydrobromide

产品货号

Axon 2307 CAS [1049743-03-4] MF C16H14N2S.HBrMW 347.27 Purity: 99% Soluble in DMSO Description Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro.About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate. KEYWORDS: ARM1 hydrobromide | supplier | LTA4H inhibitor | ARM1 HBr | CAS [1049743-03-4] | [68729-05-5] | Eicosanoid epoxides | LTA4H | Inhibitor | neutrophils | LTA4 | proinflammatory mediator | LTB4 | aminopeptidasePro-Gly-Pro | inflammation

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ARM1 hydrobromide

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2307

CAS [1049743-03-4]

MF C16H14N2S.HBr
MW 347.27

Purity: 99%
Soluble in DMSO

ARM1 hydrobromide

Description

Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro.About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate.

A. Stsiapanava et al. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc. Natl. Acad. Sci. USA. 2014, 111, 4227-4232.

Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4

Chemical name

4-(4-benzylphenyl)thiazol-2-amine hydrobromide

Parent CAS No.

[68729-05-5]

产品资料