产品名称

PF 956980

产品货号

Axon 2217 CAS [1262832-74-5] MF C18H26N6OMW 342.44 Purity: 98% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description JAK3 inhibitor and close analogue of CP 690550 (Tofacitinib; Axon 1338 and Axon 2072). Useful tool compound to study JAK3 inhibition in the treatment of various diseases, particularly asthma and COPD, and rheumatoid arthritis. References Certificates Categories Extra info A.J. Steele et al. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of (...). Blood 2010, 116(22), 4569-4577. P.S. Changelian et al. The specificity of JAK3 kinase inhibitors. Blood, 2008, 111(4), 2155-2157. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation JAK-STAT EC 2.7.10.2 JAK Pfizer Licensed Products JAK3 inhibitor; analogue of Axon 1338 and 2072 Chemical name ((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [1262832-74-5] Order Size Unit Price Stock 5 mg €90.00 In Stock

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

PF 956980

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2217

CAS [1262832-74-5]

MF C18H26N6O
MW 342.44

Purity: 98%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

PF 956980

Description

JAK3 inhibitor and close analogue of CP 690550 (Tofacitinib; Axon 1338 and Axon 2072). Useful tool compound to study JAK3 inhibition in the treatment of various diseases, particularly asthma and COPD, and rheumatoid arthritis.

A.J. Steele et al. The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of (...). Blood 2010, 116(22), 4569-4577.

P.S. Changelian et al. The specificity of JAK3 kinase inhibitors. Blood, 2008, 111(4), 2155-2157.

Cell Signaling & Oncology Epigenetics Immunology Pain & Inflammation JAK-STAT EC 2.7.10.2 JAK Pfizer Licensed Products

JAK3 inhibitor; analogue of Axon 1338 and 2072

Chemical name

((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)(pyrrolidin-1-yl)methanone

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[1262832-74-5]

产品资料