LY 333531 hydrochloride - Ruboxistaurin

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2362

CAS [169939-93-9]

MF C28H28N4O3.HCl
MW 505.01

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

LY 333531 hydrochloride

Description

Orally active protein kinase C β (PKC-β) specific inhibitor; the more water soluble mesylate salt of LY 333531 (Axon 1401) is available as well.

Ruboxistaurin: LY 333531. Drug R. D. 2007, 8(3), 193-199.

LY-333531 mesylate hydrate. Drugs Fut. 2000, 25(10), 1017.

GL Engel et al. Salt form selection and characterization of LY333531 mesylate monohydrate. Int. J. Pharmaceutics 2000, 198(2), 239-247.

MR Jirousek et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacy clohexadecene-1,3(2H)-dione (LY333531) and related analogues.... J. Med. Chem. 1996, 39, 2664.

Y Wu et al. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J. Pharmacol. Sci. 2006, 101(4), 335-343.

PKC-β inhibitor

Chemical name

13-((Dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13) oxadiazacyclohexadecene-1,3(2H)-dione hydrochloride

Parent CAS No.

[169939-94-0]

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