| 产品名称 | SB 706504 - PCG |
| 产品货号 | Axon 2444 CAS [911110-38-8] MF C24H19F3N8OMW 492.46 Purity: 98% Soluble in DMSO Description Selective p38-MAPK inhibitor that targets a subset of inflammatory macrophage genes (IC50 value 2.5 nM for p38α, and no IC50 values below 5 μM, except for JNK1 (5 µM)). When used with dexamethasone, SB 706504 causes effective suppression of these genes without affecting transcription of a subset of LPS-regulated genes, including IL-1β, IL-18, and CCL5 (genes involved in the pathogenesis of COPD). Furthermore, SB 706504 reduces TNFα, GM-CSF, and IL-6 production from LPS-stimulated COPD macrophages, with less effect on IL-8 production. KEYWORDS: SB 706504 | Supplier | p38 MAPK inhibitor | Axon Medchem | Axon 2444 | PCG | SB706504 | CAS [911110-38-8] | MAPK (p38) | Inhibitor | COPD | macrophage | inflammation | LPS | TNFα | cytokines |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
SB 706504 - PCGAxon 2444 CAS [911110-38-8] MF C24H19F3N8O
DescriptionSelective p38-MAPK inhibitor that targets a subset of inflammatory macrophage genes (IC50 value 2.5 nM for p38α, and no IC50 values below 5 μM, except for JNK1 (5 µM)). When used with dexamethasone, SB 706504 causes effective suppression of these genes without affecting transcription of a subset of LPS-regulated genes, including IL-1β, IL-18, and CCL5 (genes involved in the pathogenesis of COPD). Furthermore, SB 706504 reduces TNFα, GM-CSF, and IL-6 production from LPS-stimulated COPD macrophages, with less effect on IL-8 production. KEYWORDS: SB 706504 | Supplier | p38 MAPK inhibitor | Axon Medchem | Axon 2444 | PCG | SB706504 | CAS [911110-38-8] | MAPK (p38) | Inhibitor | COPD | macrophage | inflammation | LPS | TNFα | cytokines
Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes.
Chemical nameN-cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]-guanidine Parent CAS No.[911110-38-8] |
| 产品资料 |
