产品名称

CRT0066854

产品货号

Axon 2656 CAS [1438881-19-6] MF C24H25N5SMW 415.55 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Selective ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM, for full-length PKCζ, PKCι, respectively). CRT0066854 decreased colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. A chemical tool to further dissect PKCζ and PKCι roles in establishing cell polarity and growth-factor-stimulated signalling pathways. KEYWORDS: CRT0066854 | supplier | PKC inhibitor | CRT-0066854 | CAS [1438881-19-6] | Phosphorylation | protein kinase C | aPKC | AGC | PKCζ | PKCι | ATP | LLGL2 | colony | lumen formation | migration | zeta | iota

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

CRT0066854

Based on 15 reference(s) in Google Scholar 10 10 15

Axon 2656

CAS [1438881-19-6]

MF C24H25N5S
MW 415.55

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

CRT0066854

Description

Selective ATP-competitive inhibitor of the atypical PKC isoenzymes (IC50 values 639 nM and 132 nM, for full-length PKCζ, PKCι, respectively). CRT0066854 decreased colony formation in HeLa cells, inhibits LLGL2 phosphorylation and polarized epithelial morphogenesis, and impedes directed migration of NRK cells. A chemical tool to further dissect PKCζ and PKCι roles in establishing cell polarity and growth-factor-stimulated signalling pathways.

S Kjær et al. Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes. Biochem J. 2013 Apr 15;451(2):329-42.

M Linch et al. Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis. 2014 Feb;35(2):396-406.

Cell Signaling & Oncology Immunology Pain & Inflammation Stem Cell NF-κB MAPK PI3K-Akt-mTOR EC 2.7.11.13 PKC

Selective ATP-competitive inhibitor of the atypical PKC isoenzymes

Chemical name

(2S)-3-phenyl-N1-[5,6,7,8-tetrahydro-2-(4-pyridinyl)[1]benzothieno[2,3-d]pyrimidin-4-yl]-1,2-propanediamine

Parent CAS No.

[1438881-19-6]

产品资料