| 产品名称 | AZ 628 |
| 产品货号 | Axon 1545 CAS [878739-06-1] MF C27H25N5O2MW 451.52 Purity: 99% Soluble in DMSO Description Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF References Certificates Categories Extra info C Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008, 68(12), 4853–4861. G Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF B-Raf and C-Raf protein kinase inhibitor Chemical name 3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide Parent CAS No. [878739-06-1] Order Size Unit Price Stock 5 mg €80.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
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| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
AZ 628Axon 1545 CAS [878739-06-1] MF C27H25N5O2
Description
Selective RAF inhibitor, showing strong selectivity for RAF kinases among a panel of 150 tested kinases; IC50 values: ca 30 nM for BRAF V600E and wild-type CRAF and 100 nM for wild-type BRAF
B-Raf and C-Raf protein kinase inhibitor
Chemical name3-(Cyano-dimethyl-methyl)-N-[4-methyl-3-(3-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylamino)-phenyl]-benzamide Parent CAS No.[878739-06-1] |
| 产品资料 |
