| 产品名称 | BQU 57 |
| 产品货号 | Axon 2397 CAS [1637739-82-2] MF C16H13F3N4OMW 334.30 Purity: 99% Soluble in DMSO Description Inhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 µM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396) References Certificates Categories Extra info C. Yan et al. Small molecules inhibit the RAS-like small GTPases RALA and RALB. Cancer Discov. 2014 Nov;4(11):1251. C. Yan et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK EC 3.6.5.2 RalA RalB Inhibitor of the RAS-like small GTPases RalA and RalB Chemical name 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Parent CAS No. [1637739-82-2] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 产品价格 | 现货询价，电话：010-67529703 |
| 产品规格 | |
| 产品品牌 | axonmedchem |
| 产品概述 | |
| 产品详情 |
BQU 57Axon 2397 CAS [1637739-82-2] MF C16H13F3N4O
DescriptionInhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 µM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396)
Inhibitor of the RAS-like small GTPases RalA and RalB
Chemical name6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Parent CAS No.[1637739-82-2] |
| 产品资料 |
