产品名称

GW 5074

产品货号

Axon 1984 CAS [220904-83-6] MF #N/AMW #N/A Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent, brain-permeable inhibitor of c-Raf (IC50 value 9 nM) when tested in vitro with no effect on the activities of CDK1/2/5/6, JNK1/2/3, c-Src, MEK1, p38 MAP kinase, VEGFR2, and c-fms. In contrast to its effect in vitro, treatment of neurons with GW 5074 causes c-Raf activation (when measured in vitro inthe absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW 5074 protects neurons from death in culture and in an in vivo paradigm of neurodegeneration. KEYWORDS: GW 5074 | supplier | C-Raf inhibitor | GW5074 | CAS [220904-83-6] | MEK | RAF | Inhibitor | Raf-1 | cell-permeable | activation | Raf-MEK-ERK | pathway | CNS | neurodegeneration | neuroprotection

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

GW 5074

Based on 241 publications in PubMed 9 10 241

Axon 1984

CAS [220904-83-6]

MF #N/A
MW #N/A

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

GW 5074

Description

Potent, brain-permeable inhibitor of c-Raf (IC50 value 9 nM) when tested in vitro with no effect on the activities of CDK1/2/5/6, JNK1/2/3, c-Src, MEK1, p38 MAP kinase, VEGFR2, and c-fms. In contrast to its effect in vitro, treatment of neurons with GW 5074 causes c-Raf activation (when measured in vitro inthe absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW 5074 protects neurons from death in culture and in an in vivo paradigm of neurodegeneration.

PC Chin et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem. 2004 Aug;90(3):595-608.

K. Lackey et al. The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.

Brain-permeable inhibitor of c-Raf (in vitro) with activating effects in vivo

Chemical name

3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one

Parent CAS No.

[220904-83-6]

产品资料