Silibinin - Silybin | Silymarin I

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2487

CAS [802918-57-6]

MF C25H22O10
MW 482.44

Purity: 99%
Soluble in DMSO

Silibinin

Description

Natural flavonolignan, antihepatotoxic agent and antioxidant, exhibiting potent antitumor activities against various types of cancers. Interferes with many signaling pathways, such as notch, NF-κB, EGFR, SIRT1, PI3K/Akt and many others Mix of Silybin A and B

S. Zhang et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8(12):e83699.

J.K. Rho et al. Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation. Mol Cancer Ther. 2010 Dec;9(12):3233-43.

C. Agarwal et al. Anti-cancer efficacy of silybin derivatives -- a structure-activity relationship. PLoS One. 2013;8(3):e60074.

R. Gazák et al. Silybin and silymarin--new and emerging applications in medicine. Curr Med Chem. 2007;14(3):315-38.

Angiogenesis Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Immunology Miscellaneous Pain & Inflammation Immunomodulator Antioxidant p53-Tumor Suppression NF-κB MAPK PI3K-Akt-mTOR

Natural flavonolignan, cytoprotectant, antioxidant, and antihepatotoxic agent

Chemical name

(2R,3R)-3,5,7-trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one

Parent CAS No.

[802918-57-6]

产品资料