产品名称 AMG 232
产品货号 Axon 2639 CAS [1352066-68-2] MF C28H35Cl2NO5SMW 568.55 Purity: 100% Optical purity: Optically pure Soluble in 0.1N NaOH(aq) and DMSO Description Potent, selective, and orally bioavailable MDM2-p53 inhibitor (IC50 value 9.1 nM, Kd 0.045 nM), demonstrating remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model. Moreover, AMG 232 activates p53 pathway activity in vivo, and potentiates the activity of p53-inducing cytotoxic agents. KEYWORDS: AMG 232 | supplier | MDM2 inhibitor | AMG232 | AMG-232 | CAS [1352066-68-2] | Axon Medchem | Axon 2639 | p53 | HDM-MDM | orally bioavailable | MDM2-p53 interaction | antitumor activity | SJSA-1 | osteosarcoma | xenograft model | p21
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产品品牌 axonmedchem
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AMG 232

Based on 236 reference(s) in Google Scholar 8 10 236

Axon 2639

CAS [1352066-68-2]

MF C28H35Cl2NO5S
MW 568.55

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in 0.1N NaOH(aq) and DMSO

AMG 232

Description

Potent, selective, and orally bioavailable MDM2-p53 inhibitor (IC50 value 9.1 nM, Kd 0.045 nM), demonstrating remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model. Moreover, AMG 232 activates p53 pathway activity in vivo, and potentiates the activity of p53-inducing cytotoxic agents.

KEYWORDS: AMG 232 | supplier | MDM2 inhibitor | AMG232 | AMG-232 | CAS [1352066-68-2] | Axon Medchem | Axon 2639 | p53 | HDM-MDM | orally bioavailable | MDM2-p53 interaction | antitumor activity | SJSA-1 | osteosarcoma | xenograft model | p21

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