产品名称

JTP 0819958 - HOIPIN-1

产品货号

Axon 2939 CAS [N.A.] MF C17H13NaO4MW 304.27 Purity: 99% Soluble in water and DMSO Recently added

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JTP 0819958 - HOIPIN-1

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2939

CAS [N.A.]

MF C17H13NaO4
MW 304.27

Purity: 99%
Soluble in water and DMSO

Recently added

JTP 0819958

Description

JTP 0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor. JTP 0819958 exhibited IC50 values of 4.4, 3.5 and 3.7 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex and the HOIP/SHARPIN complex, respectively.

The prodrug JTP 1048196 is also available as Axon 2947.

K Katsuya et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF)-Based Assay System. SLAS Discov. 2018 Dec;23(10):1018-1029.

Cell Signaling & Oncology Pain & Inflammation NF-κB Ubiquitin EC 6.3.2.19 Ubiquitin Ligase (E3; LUBAC)

Selective linear ubiquitin chain assembly complex (LUBAC) inhibitor

Chemical name

Sodium (E)-2-(3-(2-methoxyphenyl)-3-oxoprop-1-enyl)benzoate

Parent CAS No.

[N.A.]

产品资料