产品名称

MHY 1485

产品货号

Axon 2425 CAS [326914-06-1] MF C17H21N7O4MW 387.39 Purity: 99% Soluble in DMSO Description mTOR activator with an inhibitory effect on autophagy. MHY1485 markedly increased the LC3II/LC3I ratio dose-dependently and time-dependently by inhibition of the fusion between autophagosomes and lysosomes, and without increasing the autophagic flux. At 2 µM, MHY1485 did not show any cell death during longer treatment, supporting that MHY1485 had less toxicity than other well-known inhibitors of autophagy. MHY1485 was also tested and found moderately active as antimalarial agent (MIC value of ca. 26 µM against P. Falciparum). References Certificates Categories Extra info Y.J. Choi et al. Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS One. 2012;7(8):e43418. A. Agarwal et al. Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents. Bioorg Med Chem Lett. 2005 Feb 1;15(3):531-3. H. Ojha et al. Quantitative structure activity relationship study of 2,4,6-trisubstituted-s-triazine derivatives as antimalarial inhibitors of Plasmodium falciparum dihydrofolate reductase. Chem Biol Drug Des. 2011 Jan;77(1):57-62. Certificate of Analysis Material Safety Data Sheet Angiogenesis Cell Signaling & Oncology Immunology mTOR PI3K-Akt-mTOR EC 2.7.11.1 Antiprotozoal agents Autophagy mTOR activator with an inhibitory effect on autophagy Chemical name 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine Parent CAS No. [326914-06-1] Order Size Unit Price Stock 10 mg €70.00 In Stock

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现货询价，电话：010-67529703

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axonmedchem

产品概述

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MHY 1485

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2425

CAS [326914-06-1]

MF C17H21N7O4
MW 387.39

Purity: 99%
Soluble in DMSO

MHY 1485

Description

mTOR activator with an inhibitory effect on autophagy. MHY1485 markedly increased the LC3II/LC3I ratio dose-dependently and time-dependently by inhibition of the fusion between autophagosomes and lysosomes, and without increasing the autophagic flux. At 2 µM, MHY1485 did not show any cell death during longer treatment, supporting that MHY1485 had less toxicity than other well-known inhibitors of autophagy. MHY1485 was also tested and found moderately active as antimalarial agent (MIC value of ca. 26 µM against P. Falciparum).