产品名称

eCF309

产品货号

Axon 2630 CAS [2001571-40-8] MF C18H21N7O3MW 383.40 Purity: 98% Moderately soluble in DMSO Description Potent inhibitor of mTOR signalling (IC50 value 10 - 15 nM in vitro and in vivo) with very high selectivity over other kinases, including PI3Ks. The selectivity profile of eCF309 is as good as or even better than that of any other selective mTOR inhibitor reported to date, making it a highly valuable probe for chemical biology and biomedicine. Note:

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产品规格

产品品牌

axonmedchem

产品概述

产品详情

eCF309

Based on 5 reference(s) in Google Scholar 10 10 5

Axon 2630

CAS [2001571-40-8]

MF C18H21N7O3
MW 383.40

Purity: 98%
Moderately soluble in DMSO

eCF309

Description

Potent inhibitor of mTOR signalling (IC50 value 10 - 15 nM in vitro and in vivo) with very high selectivity over other kinases, including PI3Ks. The selectivity profile of eCF309 is as good as or even better than that of any other selective mTOR inhibitor reported to date, making it a highly valuable probe for chemical biology and biomedicine.

Note: Produced by and sold in collaboration with University of Edinburgh

C Fraser et al. eCF309: a potent, selective and cell-permeable mTOR inhibitor. Med. Chem. Commun., 2016,7, 471-477.

C Fraser et al. Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL. J Med Chem. 2016 May 26; 59(10): 4697–4710.

Highly selective and potent inhibitor of mTOR signalling

Chemical name

5-(4-amino-1-(2,2-diethoxyethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine

Source information

* Sold in collaboration with University of Edinburgh

Parent CAS No.

[2001571-40-8]

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