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5'-DMT-G(DMF)-Suc-RNA CPG is used for the placement of G on the 3' end of oligoribonucleotides. . This support has a 2’ acetyl protecting group which is easily cleaved during deprotection. The 500 Å CPG is best suited for the synthesis of RNA sequences up to 50-mers in length. The use of this 5’-DMT protected RNA support is identical to a DNA support with the same protection groups.
Properties:
Product Usage:
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Synthesis Conditions:
Follow the instrument manufacturer's protocol when using this product.
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Cleavage Conditions:
Use concentrated ammonia for 90 minutes at 25 °C when using standard amidites or 1:1 ammonia:methylamine (AMA) for 25 minutes at 25 °C when using fast deprotecting amidites. We do not recommend using AMA to cleave or deprotect sequences that contain uridine. The AMA may degrade the uridine nucleobase.
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Deprotection Conditions:
When using fast deprotecting amidites (eg. C-Ac, G-DMF) use concentrated ammonia for 1 hour or AMA for 30 minutes at 60 °C. When using standard amidites (eg. C-Bz, G-iBu) use concentrated ammonia for 5 hours at 60 °C.
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The mass this product adds after conjugation and work-up (the additional mass seen by mass spectrometry) is:
345.2
Storage and Handling:
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Shipping Conditions:
Ambient
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Storage Conditions:
-15 to -30 °C
