The NanoAssemblr Benchtop system is designed for rapid prototyping of novel nanoparticle formulations of 1 to 15mL, that would be difficult to make with alternative manufacturing methods. Software enables the control of input mixing parameters for optimizing particle characteristics such as size and encapsulation efficiency.
The NanoAssemblr Benchtop is a nanoparticle synthesis system that gives researchers reproducibility and ease-of-use for iterating on nanoparticle formulations and therapeutic delivery experiments. Proprietary microfluidics technology enables controlled, bottom-up, molecular self-assembly of nanoparticles through millisecond mixing of components at nanolitre scale. The NanoAssemblr Benchtop is capable of manufacturing nanoparticle volumes between 1 to 20 mL per batch, which is ideal for low-cost formulation and process development. The quick and precise manufacture of nano-medicines allows for 30+ formulations in a day. Users can control size by process and composition – even tweak process parameters such as mixing ratios, flow rate and lipid composition in order to fine tune size.
The Benchtop instrument harnesses Precision NanoSystems’ microfluidic mixing technology to simplify and control the formulation of nanoparticles. The system allows the encapsulation of constructs using novel excipient design that are difficult or not possible using alternative methods. From nucleic acids to hydrophobic drugs, the Benchtop enables tuning for the optimization of nanoparticle encapsulation efficiency and payload release and activity, whether it be in liposome, lipid nanoparticle or polymeric nanoparticle approaches.
The NanoAssemblr™ Benchtop Cartridges
NanoAssemblr Microfluidic Cartridges are used with the Benchtop Instrument for the synthesis of a variety of nanoparticles (liposomes, polymeric nanoparticles, lipid nanoparticles). These disposable cartridges have a broad solvent compatibility and can be used to make nanoparticles via nanoprecipitation. The nanoparticles self-assemble while the formulation components are rapidly mixed through the microfluidic channels of the cartridges. Size and properties of the nanoparticles can be altered through the flow rate at which formulation materials are pumped through the cartridge.
- Gene delivery via high in vivo cell transfection efficiency
- Nanoparticle design
- Drug development
- Lipid nanoparticles formulation
- Liposome encapsulation
- Polymeric nanoparticles