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| Product Name | Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) (AA 27-159) protein |
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| Description | TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer Synonyms: AAT3, FAA3, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TGFR-2, TGFbeta-RII, TGFBR-2, TGF-beta receptor type-2, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TGF-beta type II receptor, TbetaR-II, TGFBR2 |
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| Size | 10 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TGFBR2|TBETA-RII|TGFBRII|1110020H15Rik|AU042018|DNIIR|RIIDN|TBR-II|TbetaR-II|TbetaRII|TGF-beta 2|Tgfbr2T|AAT3|FAA3|LDS1B|LDS2B|MFS2|RIIC|TAAD2|TGFR-2|TGFbeta-RII |
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| Gene, Accession, CAS # | Gene ID: 7048 |
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| Catalog # | ABIN806404 |
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| Order / More Info | Transforming Growth Factor, beta Receptor II (70/80kDa) (TGFBR2) (AA 27-159) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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